Senior Research Scientist at AstraZeneca

Senior Research Scientist – human induced-pluripotent stem cell biology & molecular biology at AstraZeneca in Gothenburg.

Are you an experienced scientist in the field of pluripotent stem cells (PSC)? Do you have extensive experience in molecular biology? Would you like to use your scientific skills to drive the development of stem-cell derived models for therapeutic development?

If these goals resonate with you, we have an exciting opportunity for you to join the Applied Stem Cell Sciences Team in Discovery Sciences, Biopharmaceuticals R&D at AstraZeneca in Gothenburg!

Purpose, Offer and Benefits

This is a 7-month consulting assignment starting in March. You will be employed by TNG during this period

At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you´re our kind of person.

Your Responsibilities

You will be working alongside with our stem cell scientists, disease area specialists and the genome editing group. Using your strong knowledge and experience in stem cell biology and cell model development you will have the opportunity to work on development of in vitro models and assays that will be applied to study various targets of relevance to disease. You will maintain and differentiate induced pluripotent stem cells (iPSCs) and carry out gene editing experiments where necessary.

The Bigger Picture

The role is focused on laboratory-based activities. Your biggest impact will be through significant contributions to the practical delivery to projects in compliance with AstraZeneca corporate responsibility, policies and relevant safety standards.

It is essential to have good social and communication skills, be collaborative and a dedicated team player. Candidates should be able to work independently, take their own initiatives and have a positive, goal oriented and problem-solving attitude

Our Expectations

• BSc/MSc/PhD degree with extensive experience in Developmental and Cell Biology
• Proven experience with human PSC biology and differentiation to cardiac or kidney cell types
• Experience in developing molecular biology, biochemical and cell-based assays in iPSC-derived cultures including qPCR, ELISA, Western blotting, Flow cytometry & immunofluorescence.
• Perform molecular biology protocols in support of in-house quantitative PCR, digital PCR and NGS assays.
• Effectively collaborate within a matrixed research team to facilitate the success of projects.
• Maintain complete experimental records.

The following skills are highly desirable:

• Experience with CRISPR gene editing & clonal cell line generation.
• Expertise with liquid handling automation technologies
• Experience of setting up cell based pharmacological assays
• Extensive experience in molecular biology techniques, including qPCR, fragment analysis, NGS library prep, AmpSeq, advanced cloning techniques and relevant bioinformatics tools