Senior Scientist NMR spectroscopy

We are looking for a scientist with passion and experience to join Mechanistic and Structural Biology Department, AZ in Gothenburg

Are you a scientist with expertise in, and passion for, the application of NMR to understand and determine the dynamics and structure of therapeutically relevant target proteins? Would you like to apply your expertise to impact and expand the use of NMR in drug discovery projects whilst being presented with a professional development opportunity within a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca in Gothenburg has a challenge for you!

Purpose, Offer and Benefits

This is a one-year consulting assignment starting on August 1st. You will be employed by TNG during the assignment period.

In this role, you will have a high level of control and influence over the project, allowing you to shape its direction and outcomes significantly. Additionally, you will have ample opportunities to learn new technical skills and develop leadership abilities. Our collaborative and innovative work environment enables you to work alongside scientists and postdocs from various disciplines, both within and across the global AstraZeneca community. This role offers a unique opportunity for professional development in an industrial setting, providing you with a valuable experience and additional skills and helping you build a strong foundation for your future endeavours.

Your Responsibilities

• Responsible for designing and implementing advanced pulse sequences for solution-state NMR, tailored to our specific research needs.
• Perform intricate NMR experiments aimed at the assignment and structural determination of proteins, ensuring precise and accurate data collection. 
• Analyzing NMR data, interpreting results, and integrating these findings with other research data to provide comprehensive insights into the drug mechanism of action. 
• Collaborate with multidisciplinary teams, contributing to the synthesis of NMR findings with the broader research objectives of this project. Additionally, you will stay abreast of the latest advancements in NMR spectroscopy and protein structure determination, continuously applying this knowledge to enhance our research capabilities.
• Document and present your results in both internal and external meetings, playing a vital role in driving our scientific endeavors forward.

Your findings will not only support the ongoing project but will also constitute an important part of our publication strategy, aiming for high-impact journal publications.

The Bigger Picture

The role as Senior Research Scientist is a laboratory-based position supporting the structure determination of protein-drug complexes in solution utilizing NMR spectroscopy. For this we are seeking a highly skilled and motivated NMR spectroscopist to join our Biophysics team on a one-year contract basis. The ideal candidate will have a strong theoretical and practical background in pulse sequences for solution-state NMR, along with extensive experience in the assignment and determination of protein structures using NMR techniques. This role is crucial for advancing our research and development projects in dyslipidaemia and familial hypercholesterolemia.

Our Expectations

• Ph.D. or equivalent in Chemistry, Biochemistry, or a related field with a focus on NMR spectroscopy.
• Proven experience in pulse sequence development and application for solution-state NMR.
• Demonstrated expertise in the assignment and determination of protein structures using NMR.
• Proficient in NMR data analysis software and tools and demonstrated ability to communicate data interpretation clearly.
• Familiarity in the general application of biophysical methods for the study of molecular interactions.
• Proven reputation gained through an excellent track record of publications and/or conference presentations.

To be successful in this role we see that you have good social and communication skills, are collaborative and a strong team player. You should also be able to work independently and have a positive, goal oriented and problem-solving attitude.